Protein Sequencing by Expansion (ProSE™)

Protein Sequencing
by Expansion (ProSE™)
Advancing life science discovery with massively parallel, single-molecule 
proteome sequencing

Introducing ProSE™

Introducing ProSE™

Technology

ProSE™ will revolutionize proteomics by delivering unprecedented precision, scalability, and accessibility.

1

Sample Preparation

To prepare samples for ProSE, proteins and peptides are first functionalized by attaching an initiating linker to one terminus of each peptide chain.
2

Molecular Expansion

Each amino acid is then sequentially added and uniformly spaced along the linker in its original order, constructing a ProSE Molecule.
3

Amino Acid Sequencing

Finally, the assembled ProSE Molecule passes through a nanopore, where distinct electrical signatures from each amino acid reveal the protein’s sequence.
Protein Sequencing by Expansion (ProSE™) leverages spatial expansion of amino acids from proteins to enable single amino acid discrimination of all 20 amino acids and PTMs.

Glyphic biotechnologies

1

Sample Peparation

REAGENT KITS FUNCTIONALIZE PEPTIDES

2

MOLECULAR EXPANSION

ORDERED EXPANSION OF AMINO ACIDS

3

AMINO ACID SEQUENCING

UNBIASED DISCRIMINATION OF ALL 20 AAs + PTMs

Glyphic Biotechnologies

Glyphic Biotechnologies
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Glyphic biotechnologies

Glyphic Biotechnologies, Inc. is developing the first truly de novo high-throughput proteome sequencing technology capable of discriminating all 20 AAs and PTMs accurately with single molecule sensitivity.

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Protein Sequencing by Expansion (ProSE™)

Protein Sequencing by Expansion (ProSE™)

Founded in 2021 and headquartered in Berkeley (CA), Glyphic Biotechnologies exists to fundamentally rewrite the rules of proteomics.

We believe proteome sequencing will be one of the defining technologies of the 21st century. The precision, scalability, and accessibility of Glyphic’s Protein Sequencing by Expansion (ProSE™) will enable the development of critical first-in-class therapies, and deeper insights into life itself.

Careers

Careers
At Glyphic Biotechnologies, we hire exceptional candidates motivated by solving complex, meaningful problems. Join our talented team in shaping the future of proteomics worldwide.

Open positions

Scientist, Platform Development

  • Berkeley, California, United States

  • Platform Development

$109K – $144K

(Senior) Director of Chemistry

  • Berkeley, California, United States

  • Research & Development

$189K – $258K

Senior/Staff Scientist, Biopolymer Chemistry

  • Berkeley, California, United States

  • Research & Development

$120K – $183K

Senior/Staff Scientist, Data Science

  • Berkeley, California, United States

  • Data Science

$168K – $238K

Senior/Staff Scientist, Surface Chemistry

  • Berkeley, California, United States

  • Research & Development

$120K – $183K

Vice President, Platform Development

  • Berkeley, California, United States

  • Platform Development

$239K – $296K

Write Your Next Chapter
Write Your Next Chapter
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The next great chapter of scientific discovery will be written in ProSE™

Contact

Contact

Information

A:

3100 San Pablo Ave. #201 Berkeley, CA 94702

E:

letschat@glyphic.bio

S:

Get in Touch!

Get in Touch!

Compose the Future with Us